Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions.

ABSTRACT: The Bacopa monnieri plant contains phytochemicals that have been used extensively in traditional medicine to treat various diseases. More recently it has been shown to accelerate wound healing, though its mechanism of action is largely unknown. Here we investigated the cellular pathways activated by a methanol extract of Bacopa monnieri in human dermal fibroblasts, which play many critical roles in the wound healing program. Gene expression analysis revealed that the Bacopa monnieri extract can modulate multiple processes involved in the wound healing program such as migration, proliferation, and angiogenesis. We discovered that the extract can increase migration of fibroblasts via modulating the size and number of focal adhesions. Bacopa monnieri-mediated chang

SUBMITTER: Zirmire RK 

PROVIDER: S-EPMC10981128 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature