OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial.

ABSTRACT:

Purpose

To determine if performing the isometric handgrip test (IHGT) can augment optical coherence tomography angiography (OCTA) vascular signal quality in eyes with macular abnormalities.

Methods

A randomized, single-blinded crossover trial was conducted including 36 participants with macular abnormalities, randomized to undergo OCTA with or without the IHGT, then crossed over to the alternate "intervention" after 1 minute. The primary outcome was OCTA signal quality after 1 minute of squeezing at 50% maximum grip strength. Secondary outcomes were other measures of vascular flow and systemic blood pressure (BP), also regressed against person- and eye-level covariables.

Results

Primary analysis of OCTA signal quality with versus without the IHGT was nonsignificant (P

SUBMITTER: Trinh M 

PROVIDER: S-EPMC10981163 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature