Time interval between surgery and adjuvant chemotherapy in patients with gastric cancer after gastrectomy: a population-based cohort study using a nationwide claim database.

ABSTRACT:

Background

Adjuvant chemotherapy can reduce recurrence rates by eradicating microscopic metastases which may persist after curative resection. However, the optimal time interval (TI) between the surgery and chemotherapy remains controversial.

Objectives

This study investigated the optimal TI between surgery and chemotherapy.

Design

A population-based cohort study using a nationwide claims database.

Methods

The data were obtained from the Korean National Health Insurance Service (NHIS) of Korea. We included patients who underwent gastrectomy between 2013 and 2018. To determine the optimal cutoff point of TI, a restricted cubic spline Cox regression model was established, and categorized the population into three groups based on TI: the early (⩽20 days), the late

SUBMITTER: Maeng CH 

PROVIDER: S-EPMC10981231 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature