Treatment switches of disease-modifying therapies in people with multiple sclerosis: long-term experience from the German MS Registry.

ABSTRACT:

Background

The spectrum of disease-modifying therapies (DMTs) for people with multiple sclerosis (PwMS) has expanded over years, but data on treatment strategies is largely lacking. DMT switches are common clinical practice.

Objective

To compare switchers and non-switchers, characterize the first DMT switch and identify reasons and predictors for switching the first DMT.

Methods

Data on 2722 PwMS from the German MS Registry were retrospectively analyzed regarding sociodemographic/clinical differences between 1361 switchers (PwMS discontinuing the first DMT) and non-switchers matched according to age, sex, and observation period. Frequencies of first and second DMTs were calculated and switch reasons identified. Predictors for DMT switches were revealed using univariab

SUBMITTER: Frahm N 

PROVIDER: S-EPMC10981260 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature