Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis.

ABSTRACT:

Background

Patients on hemodialysis have a higher burden of cognitive impairment than individuals of the same age in the general population. Studies have found a link between cognition and skeletal muscle function. However, few studies have investigated these associations and the underlying mechanisms in patients on hemodialysis.

Methods

A total of 166 patients on hemodialysis were enrolled in this longitudinal study. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) scores. Skeletal muscle indicators were evaluated using Inbody S10. Plasma brain-derived neurotrophic factor (BDNF) concentrations were measured by enzyme-linked immunosorbent assay. The primary outcome was a change in the MoCA scores. A mediation analysis was performed to examine the indir

SUBMITTER: Wang L 

PROVIDER: S-EPMC10981270 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature