Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus.

ABSTRACT:

Background

In this study, we evaluated the lipidome alterations caused by type 1 diabetes (T1D) and type 2 diabetes (T2D), by determining lipids significantly associated with diabetes overall and in both sexes, and lipids associated with the glycaemic state.

Methods

An untargeted lipidomic analysis was performed to measure the lipid profiles of 360 subjects (91 T1D, 91 T2D, 74 with prediabetes and 104 controls (CT)) without cardiovascular and/or chronic kidney disease. Ultra-high performance liquid chromatography-electrospray ionization mass spectrometry (UHPLC-ESI-MS) was conducted in two ion modes (positive and negative). We used multiple linear regression models to (1) assess the association between each lipid feature and each condition, (2) determine sex-specific differe

SUBMITTER: Barranco-Altirriba M 

PROVIDER: S-EPMC10981308 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature