Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease.

ABSTRACT: Neuroinflammation is one of the core pathological features of Parkinson's disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells in the brain, exhibit innate immune memory effects and are recognized as key regulators of neuroinflammatory responses. Persistent modifications of microglia provoked by the first stimuli are pivotal for innate immune memory, resulting in an enhanced or suppressed immune response to second stimuli, which is known as innate immune training and innate immune tolerance, respectively. In this study, LPS was used to establish in vitro and in vivo models of innate immune memory. Microglia-specific Hif-1α knockout mice were further employed to elucidate the regulatory role of HIF-1α in innate immune memor

SUBMITTER: Dong H 

PROVIDER: S-EPMC10981320 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature