Optimal Management of Refractory Crohn's Disease: Current Landscape and Future Direction.

ABSTRACT: Refractory Crohn's disease, defined as ongoing inflammation despite the trial of multiple advanced therapies, impacts a number of individuals with Crohn's disease, and leads to significant burden in quality of life and cost. Interventions such as early implementation of advanced therapies, optimization of current therapies prior to switching to an alternative, as well as understanding the overlapping pathophysiology between immune-mediated disorders, however, can help shift the current landscape and reduce the number of patients with refractory disease. As such, in this review we summarize the key takeaways of the latest research in the management of moderate-to-severe Crohn's disease, focusing on maximization of our currently available medications, while also exploring topics such as comb

SUBMITTER: Lee KE 

PROVIDER: S-EPMC10981422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature