Dataset Information

Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study.

ABSTRACT:

Aims

Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVDs). The composition and abundance of gut microbiota trophic networks differ between ethnicities. We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes.

Methods and results

We included cross-sectional data from 3860 individuals without CVD history from 6 ethnicities living in the Amsterdam region participating in the prospective Healthy Life in Urban Setting (HELIUS) study. Genetic variants were genotyped, faecal gut microbiota were profiled, and blood and anthropometric parameters were measured. A machine learning approach was used to assess the relationship between CVD risk (Framingham score) and gut microbiota stratified by ethnicity. Potential causal relationships between gut microbiota composition and CVD were inferred by performing two-sample Mendelian randomization with hard CVD events from the Pan-UK Biobank and microbiome genome-wide association studies summary data from a subset of the HELIUS cohort (n = 4117). Microbial taxa identified to be associated with CVD by machine learning and Mendelian randomization were often ethnic-specific, but some concordance across ethnicities was found. The microbes Akkermansia muciniphila and Ruminococcaceae UCG-002 were protective against ischaemic heart disease in African-Surinamese and Moroccans, respectively. We identified a strong inverse association between blood lipids, CVD risk, and the combined abundance of the correlated microbes Christensenellaceae-Methanobrevibacter-Ruminococcaceae (CMR). The CMR cluster was also identified in two independent cohorts and the association with triglycerides was replicated.

Conclusion

Certain gut microbes can have a potentially causal relationship with CVD events, with possible ethnic-specific effects. We identified a trophic network centred around Christensenellaceae, Methanobrevibacter, and various Ruminococcaceae, frequently lacking in South-Asian Surinamese, to be protective against CVD risk and associated with low triglyceride levels.

SUBMITTER: Warmbrunn MV

PROVIDER: S-EPMC10981523 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study.

Warmbrunn Moritz V MV Boulund Ulrika U Aron-Wisnewsky Judith J de Goffau Marcus C MC Abeka Rosamel E RE Davids Mark M Bresser Lucas R F LRF Levin Evgeni E Clement Karine K Galenkamp Henrike H Ferwerda Bart B van den Born Bert-Jan J H BJH Kurilshikov Alexander A Fu Jingyuan J Zwinderman Aeilko H AH Soeters Maarten R MR van Raalte Daniel H DH Herrema Hilde H Groen Albert K AK Nieuwdorp Max M

Cardiovascular research 20240301 4

<h4>Aims</h4>Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVDs). The composition and abundance of gut microbiota trophic networks differ between ethnicities. We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes.<h4>Methods and results</h4>We included cross-sectional data from 3860 individuals without CVD history from 6 ethnicities living in the Amsterdam region participating in the prospective Healthy Life in Urban ...[more]

PMID: 38289866

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Dataset Information

Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study.

Aims

Methods and results

Conclusion

Publications

Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study.

Similar Datasets

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