Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study.

ABSTRACT:

Aims

Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVDs). The composition and abundance of gut microbiota trophic networks differ between ethnicities. We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes.

Methods and results

We included cross-sectional data from 3860 individuals without CVD history from 6 ethnicities living in the Amsterdam region participating in the prospective Healthy Life in Urban Setting (HELIUS) study. Genetic variants were genotyped, faecal gut microbiota were profiled, and blood and anthropometric parameters were measured. A machine learning approach was used to assess the relationship between CVD risk (Framingham score) and gut microbiota stratified by ethnicity. Potenti

SUBMITTER: Warmbrunn MV 

PROVIDER: S-EPMC10981523 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature