IL-23 induces CLEC5A⁺ IL-17A⁺ neutrophils and elicit skin inflammation associated with psoriatic arthritis.

ABSTRACT: IL-23-activation of IL-17 producing T cells is involved in many rheumatic diseases. Herein, we investigate the role of IL-23 in the activation of myeloid cell subsets that contribute to skin inflammation in mice and man. IL-23 gene transfer in WT, IL-23R^GFP reporter mice and subsequent analysis with spectral cytometry show that IL-23 regulates early innate immune events by inducing the expansion of a myeloid MDL1⁺CD11b⁺Ly6G⁺ population that dictates epidermal hyperplasia, acanthosis, and parakeratosis; hallmark pathologic features of psoriasis. Genetic ablation of MDL-1, a major PU.1 transcriptional target during myeloid differentiation exclusively expressed in myeloid cells, completely prevents IL-23-pathology. Moreover, we show that IL-23-induc

SUBMITTER: Furuya H 

PROVIDER: S-EPMC10981569 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature