PGRN inhibits CD8⁺T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.

ABSTRACT:

Background

Tumor microenvironment actually reduces antitumor effect against the immune attack by exclusion of CD8⁺T cells. Progranulin (PGRN) is a multifunctional growth factor with significant pathological effects in multiple tumors; however, its role in immunity evasion of breast cancer (BCa) is not completely understood.

Methods

We depleted GRN (PGRN gene) genetically in mice or specifically in PY8119 murine BCa cell line, and mouse models of orthotopic or subcutaneous transplantation were used. Chimeric mice-deficient of PGRN (Grn^-/-) in bone marrow (BM) compartment was also generated. Association of PGRN expression with chemokine production or BCa development was investigated by histological and immunological assays.

Results

We found PGRN wa

SUBMITTER: Zhou T 

PROVIDER: S-EPMC10981592 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature