Advances in phage-host interaction prediction: in silico method enhances the development of phage therapies.

ABSTRACT: Phages can specifically recognize and kill bacteria, which lead to important application value of bacteriophage in bacterial identification and typing, livestock aquaculture and treatment of human bacterial infection. Considering the variety of human-infected bacteria and the continuous discovery of numerous pathogenic bacteria, screening suitable therapeutic phages that are capable of infecting pathogens from massive phage databases has been a principal step in phage therapy design. Experimental methods to identify phage-host interaction (PHI) are time-consuming and expensive; high-throughput computational method to predict PHI is therefore a potential substitute. Here, we systemically review bioinformatic methods for predicting PHI, introduce reference databases and in silico models appl

SUBMITTER: Nie W 

PROVIDER: S-EPMC10981677 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature