Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment.

ABSTRACT: There is widespread overlap across major psychiatric disorders, and this is the case at different levels of observations, from genetic variants to brain structures and function and to symptoms. However, it remains unknown to what extent these commonalities at different levels of observation map onto each other. Here, we systematically review and compare the degree of similarity between psychiatric disorders at all available levels of observation. We searched PubMed and EMBASE between January 1, 2009 and September 8, 2022. We included original studies comparing at least four of the following five diagnostic groups: Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Autism Spectrum Disorder, and Attention Deficit Hyperactivity Disorder, with measures of similarities between all diso

SUBMITTER: Bourque VR 

PROVIDER: S-EPMC10981737 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature