Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation.

ABSTRACT: Obesity is a growing concern in human and equine populations, predisposing to metabolic pathologies and reproductive disturbances. Cellular lipid accumulation and mitochondrial dysfunction play an important role in the pathologic consequences of obesity, which may be mitigated by dietary interventions targeting these processes. We hypothesized that obesity in the mare promotes follicular lipid accumulation and altered mitochondrial function of oocytes and granulosa cells, potentially contributing to impaired fertility in this population. We also predicted that these effects could be mitigated by dietary supplementation with a combination of targeted nutrients to improve follicular cell metabolism. Twenty mares were grouped as: Normal Weight [NW, n = 6, body condition score (BCS) 5.7 ± 0.3]

SUBMITTER: Catandi GD 

PROVIDER: S-EPMC10981747 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature