Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.

ABSTRACT:

Background

Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacking. This study aimed to investigate the role of AXT in small airway remodeling in COPD and its underlying mechanisms.

Methods

First, the model of COPD mice was established by cigarette smoke (CS) exposure combined with intraperitoneal injection of cigarette smoke extract (CSE). The effects of AXT on the morphology of CS combined with CSE -induced emphysema, EMT, and small airway remodeling by using Hemato

SUBMITTER: Ding H 

PROVIDER: S-EPMC10981815 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature