Development of membrane protein-based vaccine against lumpy skin disease virus (LSDV) using immunoinformatic tools.

ABSTRACT:

Introduction

Lumpy skin disease, an economically significant bovine illness, is now found in previously unheard-of geographic regions. Vaccination is one of the most important ways to stop its further spread.

Aim

Therefore, in this study, we applied advanced immunoinformatics approaches to design and develop an effective lumpy skin disease virus (LSDV) vaccine.

Methods

The membrane glycoprotein was selected for prediction of the different B- and T-cell epitopes by using the immune epitope database. The selected B- and T-cell epitopes were combined with the appropriate linkers and adjuvant resulted in a vaccine chimera construct. Bioinformatics tools were used to predict, refine and validate the 2D, 3D structures and for molecular docking with toll-like receptor 4 usin

SUBMITTER: Salauddin M 

PROVIDER: S-EPMC10981917 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature