Androgen deprivation therapy-related fracture risk in prostate cancer: an insurance claims database study in Japan.

ABSTRACT:

Introduction

Androgen deprivation therapy (ADT) is widely used for the treatment of prostate cancer. ADT is associated with reduced bone density leading to an increased risk of osteoporotic fracture. The objective of this retrospective cohort study was to quantify fracture risk in men treated with ADT for prostate cancer in real-world practice in Japan.

Materials and methods

Data were extracted from the Japanese Medical Data Vision (MDV) database. Men initiating ADT for treatment of prostate cancer between April 2010 and March 2021 were identified and matched to a cohort of prostate cancer patients not taking ADT using a propensity score. Fracture rates were estimated by a cumulative incidence function and compared between cohorts using a Cox cause-specific hazard model. Inf

SUBMITTER: Matsushima H 

PROVIDER: S-EPMC10982088 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature