Long-term effects of denosumab on bone mineral density and turnover markers in patients undergoing hemodialysis.

ABSTRACT:

Introduction

Denosumab, a fully human anti-RANKL monoclonal antibody, is a widely used osteoporosis treatment that is increasingly being used in patients undergoing dialysis; however, its long-term efficacy and safety in these patients remain unknown.

Materials and methods

This observational study comprised individuals aged ≥ 20 years undergoing hemodialysis and receiving denosumab. After denosumab administration, we analyzed the long-term changes in bone mineral density (BMD) and levels of bone turnover markers (BTMs) and calcium.

Results

The study included 45 patients who have been receiving denosumab for a median duration of 3.8 (interquartile range, 2.5-6.7) years. Tartrate-resistant acid phosphatase 5b (TRACP-5b) levels decreased from a median of 595 (434-778) mU

SUBMITTER: Kato K 

PROVIDER: S-EPMC10982096 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature