Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro.

ABSTRACT:

Introduction

Osteoporosis is a global health issue. Bisphosphonates that are commonly used to treat osteoporosis suppress both bone resorption and subsequent bone formation. Inhibition of cathepsin K, a cysteine proteinase secreted by osteoclasts, was reported to suppress bone resorption while preserving or increasing bone formation. Analyses of the different effects of antiresorptive reagents such as bisphosphonates and cysteine proteinase inhibitors will contribute to the understanding of the mechanisms underlying bone remodeling.

Materials and methods

Our team has developed an in vitro system in which bone remodeling can be temporally observed at the cellular level by 2-photon microscopy. We used this system in the present study to examine the effects of the cysteine prot

SUBMITTER: Ono S 

PROVIDER: S-EPMC10982105 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature