Fat mass and obesity-associated protein (FTO) mediated m⁶A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.

ABSTRACT: Gastric cancer (GC) is a common malignant tumor worldwide, especially in East Asia, with high incidence and mortality rate. Epigenetic modifications have been reported to participate in the progression of gastric cancer, among which m⁶A is the most abundant and important chemical modification in RNAs. Fat mass and obesity-associated protein (FTO) is the first identified RNA demethylase but little is known about its role in gastric cancer. In our study, data from TCGA and clinical samples showed that FTO was highly expressed in gastric cancer tissues. Kaplan-Meier plotter suggested that patients with the high level of FTO had a poor prognosis. In vitro and in vivo experiments confirmed the role of FTO in promoting gastric cancer cell proliferation. Mechanistically, we found that

SUBMITTER: Wu X 

PROVIDER: S-EPMC10982225 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature