Association between non-scarring alopecia and hypothyroidism: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Non-scarring alopecia is typically represented by two main types: alopecia areata (AA) and androgenetic alopecia (AGA). While previous observational studies have indicated a link between non-scarring alopecia and hypothyroidism, the precise causal relationship remains uncertain. To determine the potential links between non-scarring alopecia and hypothyroidism, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

We used independent genetic instruments from the FinnGen consortium for AA (682 cases, 361,140 controls) and AGA (195 cases, 201,019 controls) to investigate the association with hypothyroidism in the UK Biobank study (22,687 cases, 440,246 controls). The primary analysis was performed using the inverse variance-weighted m

SUBMITTER: Yang J 

PROVIDER: S-EPMC10982309 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature