Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study.

ABSTRACT:

Objective

While observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood. Immune cell surface antigens are actively involved in the biological behavior of immune cells, investigating immune cell surface antigens could deepen our comprehension of their role and biological processes in stroke recovery. Therefore, we aimed to investigate the immunological basis of stroke outcome by exploring the causal relationship between immune cell surface antigens and functional outcome after ischemic stroke in a Mendelian randomization study.

Methods

Genetic variants related to immune cell surface antigens and post-stroke functional outcome were selected for two-sample Mendelian randomization (MR) analysis. 389 fl

SUBMITTER: Sun W 

PROVIDER: S-EPMC10982317 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature