Identification of multiple transcription factor genes potentially involved in the development of electrosensory <i>versus</i> mechanosensory lateral line organs.

ABSTRACT: In electroreceptive jawed vertebrates, embryonic lateral line placodes give rise to electrosensory ampullary organs as well as mechanosensory neuromasts. Previous reports of shared gene expression suggest that conserved mechanisms underlie electroreceptor and mechanosensory hair cell development and that electroreceptors evolved as a transcriptionally related "sister cell type" to hair cells. We previously identified only one transcription factor gene, Neurod4, as ampullary organ-restricted in the developing lateral line system of a chondrostean ray-finned fish, the Mississippi paddlefish (Polyodon spathula). The other 16 transcription factor genes we previously validated in paddlefish were expressed in both ampullary organs and neuromasts. Here, we used our published lateral

SUBMITTER: Minarik M 

PROVIDER: S-EPMC10982350 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature