Prognostic significance of β2-microglobulin decline index in multiple myeloma.

ABSTRACT:

Purpose

To assess the prognostic significance of β2-microglobulin decline index (β2M DI) in multiple myeloma (MM).

Methods

150 MM patients diagnosed with MM were enrolled in this study. Cox proportional hazards model was used to analyze the uni- and multivariate prognosis in training cohort (n=105). A new combined prognostic model containing β2M DI was built up based on the data in training cohort. The validation group was used to verify the model.

Results

β2M DI showed significant correlation with prognosis in both uni- and multivariate analyses and had a good correlation with complete response (CR) rate and deep remission rate. The ROC and calibration curves in validation cohort (n=45) indicated a good predictive performance of the new model. Based on the median ris

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10982376 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature