JNK signaling mediates acute rejection via activating autophagy of CD8⁺ T cells after liver transplantation in rats.

ABSTRACT:

Background

Acute rejection (AR) after liver transplantation (LT) remains an important factor affecting the prognosis of patients. CD8⁺ T cells are considered to be important regulatory T lymphocytes involved in AR after LT. Our previous study confirmed that autophagy mediated AR by promoting activation and proliferation of CD8⁺ T cells. However, the underlying mechanisms regulating autophagy in CD8⁺ T cells during AR remain unclear.

Methods

Human liver biopsy specimens of AR after orthotopic LT were collected to assess the relationship between JNK and CD8⁺ T cells autophagy. The effect of JNK inhibition on CD8⁺ T cells autophagy and its role in AR were further examined in rats. Besides, the underlying mechanisms how JNK

SUBMITTER: Wang X 

PROVIDER: S-EPMC10982410 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature