Pathogenomes and virulence profiles of representative big six non-O157 serogroup Shiga toxin-producing <i>Escherichia coli</i>.

ABSTRACT: Shiga toxin (Stx)-producing Escherichia coli (STEC) of non-O157:H7 serotypes are responsible for global and widespread human food-borne disease. Among these serogroups, O26, O45, O103, O111, O121, and O145 account for the majority of clinical infections and are colloquially referred to as the "Big Six." The "Big Six" strain panel we sequenced and analyzed in this study are reference type cultures comprised of six strains representing each of the non-O157 STEC serogroups curated and distributed by the American Type Culture Collection (ATCC) as a resource to the research community under panel number ATCC MP-9. The application of long- and short-read hybrid sequencing yielded closed chromosomes and a total of 14 plasmids of diverse functions. Through high-resolution comparative phyloge

SUBMITTER: Kalalah AA 

PROVIDER: S-EPMC10982417 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature