Spectral exponent assessment and neurofilament light chain: a comprehensive approach to describe recovery patterns in stroke.

ABSTRACT:

Introduction

Understanding the residual recovery potential in stroke patients is crucial for tailoring effective neurorehabilitation programs. We propose using EEG and plasmatic Neurofilament light chain (NfL) levels as a model to depict longitudinal patterns of stroke recovery.

Methods

We enrolled 13 patients (4 female, mean age 74.7 ± 8.8) who underwent stroke in the previous month and were hospitalized for 2-months rehabilitation. Patients underwent blood withdrawal, clinical evaluation and high-definition EEG at T1 (first week of rehabilitation) and at T2 (53 ± 10 days after). We assessed the levels of NfL and we analyzed the EEG signal extracting Spectral Exponent (SE) values. We compared our variables between the two timepoint and between cortical and non-cortic

SUBMITTER: Lanzone J 

PROVIDER: S-EPMC10982436 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature