Cross-talk between the gut microbiota and hypothyroidism: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Multiple observational studies suggest a connection between the composition of the gut microbiota and hypothyroidism. However, it has yet to be determined whether the gut microbiota has a causal effect on hypothyroidism.

Methods

To investigate the connection between the gut microbiota and hypothyroidism, two-sample Mendelian randomization was performed using data from a genome-wide association study meta-analysis (n = 18,430) conducted by the MiBioGen consortium. Summary statistics for hypothyroidism (26,342 cases and 59,827 controls) were obtained using the data from the FinnGen consortium R8 release data. To investigate the causal link between the gut microbiota and hypothyroidism, various methods, including MR-Egger, weighted median, weighted model, simp

SUBMITTER: Shi C 

PROVIDER: S-EPMC10982496 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature