Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research.

ABSTRACT:

Background

Gut microbiota has been associated with dermatological problems in earlier observational studies. However, it is unclear whether gut microbiota has a causal function in dermatological diseases.

Methods

Thirteen dermatological diseases were the subject of bidirectional Mendelian randomization (MR) research aimed at identifying potential causal links between gut microbiota and these diseases. Summary statistics for the Genome-Wide Association Study (GWAS) of gut microbiota and dermatological diseases were obtained from public datasets. With the goal of evaluating the causal estimates, five acknowledged MR approaches were utilized along with multiple testing corrections, with inverse variance weighted (IVW) regression serving as the main methodology. Regarding the ta

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10982508 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature