Impact of Sonic Hedgehog-dependent sphenoid bone defect on craniofacial growth.

ABSTRACT:

Objectives

The main objective of this study was to evaluate how an apparently minor anomaly of the sphenoid bone, observed in a haploinsufficient mouse model for Sonic Hedgehog (Shh), affects the growth of the adult craniofacial region. This study aims to provide valuable information to orthodontists when making decisions regarding individuals carrying SHH mutation.

Materials and methods

The skulls of embryonic, juvenile and adult mice of two genotypes (Shh heterozygous and wild type) were examined and measured using landmark-based linear dimensions. Additionally, we analysed the clinical characteristics of a group of patients and their relatives with SHH gene mutations.

Results

In the viable Shh^{+/ -} mouse model, bred on a C57BL/6J background, we

SUBMITTER: Guyodo H 

PROVIDER: S-EPMC10982674 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature