Chd8 haploinsufficiency impacts rearing experience in C57BL/6 mice.

ABSTRACT: Mutations in CHD8 are one of the highest genetic risk factors for autism spectrum disorder. Studies in mice that investigate underlying mechanisms have shown Chd8 haploinsufficient mice display some trait disruptions that mimic clinical phenotypes, although inconsistencies have been reported in some traits across different models on the same strain background. One source of variation across studies may be the impact of Chd8 haploinsufficiency on maternal-offspring interactions. While differences in maternal care as a function of Chd8 genotype have not been studied directly, a previous study showed that pup survival was reduced when reared by Chd8 heterozygous dams compared with wild-type (WT) dams, suggesting altered maternal care as a function of Chd8 genotype. Through systematic observat

SUBMITTER: Tabbaa M 

PROVIDER: S-EPMC10982810 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature