Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study.

ABSTRACT:

Introduction

The causal association between modifiable risk factors and erectile dysfunction (ED) remains unclear, which hinders the early identification and intervention of patients with ED. The present study aimed to clarify the causal association between 42 predominant risk factors and ED.

Methods

Univariate Mendelian Randomization (MR), multivariate MR, and mediation MR analyses were used to investigate the causal association between 42 modifiable risk factors and ED. Combined results were pooled from two independent ED genome-wide association studies to verify the findings.

Results

Genetically predicted body mass index (BMI), waist circumference, trunk fat mass, whole body fat mass, poor overall health rating, type 2 diabetes, basal metabolic rate, adiponectin, c

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC10982860 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature