Retinoic acid enhances ovarian steroidogenesis by regulating granulosa cell proliferation and MESP2/STAR/CYP11A1 pathway.

ABSTRACT:

Introduction

Ovarian steroidogenesis not only affects the embryonic development and pregnancy outcome, but also associates with many diseases in mammals and women. Exploring the nutrients and mechanisms influencing ovarian steroidogenesis is critical to maintaining the optimal reproductive performance, as well as guaranteeing body health.

Objectives

This research aimed to explore the effect of retinol metabolism on ovarian steroidogenesis and the underlying mechanisms.

Methods

Comparative transcriptomic analysis of ovaries from normal and low reproductive performance sows were performed to identify the main causes leading to low fertility. The metabolites regulating steroid hormones synthesis were investigated in ovarian granulosa cells. Gene interference, overexpress

SUBMITTER: Cai S 

PROVIDER: S-EPMC10982869 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature