Immunoregulation in cancer-associated cachexia.

ABSTRACT:

Background

Cancer-associated cachexia is a multi-organ disorder associated with progressive weight loss due to a variable combination of anorexia, systemic inflammation and excessive energy wasting. Considering the importance of immunoregulation in cachexia, it still lacks a complete understanding of the immunological mechanisms in cachectic progression.

Aim of review

Our aim here is to describe the complex immunoregulatory system in cachexia. We summarize the effects and translational potential of the immune system on the development of cancer-associated cachexia and we attempt to conclude with thoughts on precise and integrated therapeutic strategies under the complex immunological context of cachexia.

Key scientific concepts of review

This review is focused on thre

SUBMITTER: Wu Q 

PROVIDER: S-EPMC10982873 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature