Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices.

ABSTRACT: The human gut microbiota is influenced by various factors, including health status and environmental conditions, yet considerable inter-individual differences remain unexplained. Previous studies identified that the gut microbiota of men who have sex with men (MSM) is distinct from that of non-MSM. Here, we reveal through species-level microbiota analysis using shotgun metagenomics that the gut microbiota of many MSM with Western origin resembles gut microbial communities of non-Westernized populations. Specifically, MSM gut microbiomes are frequently dominated by members of the Prevotellaceae family, including co-colonization of species from the Segatella copri complex and unknown Prevotellaceae members. Questionnaire-based analysis exploring inter-individual differences in MSM links spec

SUBMITTER: Huang KD 

PROVIDER: S-EPMC10982974 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature