Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice.

ABSTRACT: Tissue regeneration following an injury requires dynamic cell-state transitions that allow for establishing the cell identities required for the restoration of tissue homeostasis and function. Here, we present a biochemical intervention that induces an intermediate cell state mirroring a transition identified during normal differentiation of myoblasts and other multipotent and pluripotent cells to mature cells. When applied in somatic differentiated cells, the intervention, composed of one-carbon metabolites, reduces some dedifferentiation markers without losing the lineage identity, thus inducing limited reprogramming into a more flexible cell state. Moreover, the intervention enabled accelerated repair after muscle injury in young and aged mice. Overall, our study uncovers a conserved bi

SUBMITTER: Hernandez-Benitez R 

PROVIDER: S-EPMC10983034 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature