Circulating ceramide levels and ratios in Emirati youth under 18 years: associations with cardiometabolic risk factors.

ABSTRACT:

Background

Circulating ceramide (Cer) drives various pathological processes associated with cardiovascular diseases, liver illness, and diabetes mellitus. Although recognized as predictors of cardiometabolic diseases (CMD) in research and clinical settings, their potential for predicting CMD risk in individuals under 18 remains unexplored.

Objectives

This study was designed to utilize Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methodology to determine the biological reference ranges for Cer in plasma samples of Emirati children and develop a risk assessment score (CERT-1) based on Cer concentrations.

Methods

Using LC-MS/MS, we developed a method to measure five Cer species in plasma samples of 582 Emirati participants aged 5-17. We used the circulating concent

SUBMITTER: Shalaby YM 

PROVIDER: S-EPMC10983633 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature