Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.

ABSTRACT:

Background

Gait disturbance is common in older adults with vascular diseases. However, how carotid atherosclerosis affects gait remains poorly understood. The objectives were to investigate the associations between carotid intima-media thickness and specific gait performances and explore the potential role of brain structure in mediating these associations.

Methods

A cross-sectional analysis of data from the Taizhou Imaging Study was conducted, including 707 individuals who underwent both gait and carotid ultrasound examinations. Gait assessments include the Timed-Up-and-Go test, the Tinetti test, and quantitative gait assessment using a wearable device. Quantitative parameters were summarized into independent gait domains with factor analysis. Magnetic resonance images were

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10983675 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature