Assessment and clinical utility of metagenomic next-generation sequencing for suspected lower respiratory tract infections.

ABSTRACT:

Objectives

This study aims to compare the diagnostic efficacy of metagenomic next-generation sequencing (mNGS) to traditional diagnostic methods in patients with lower respiratory tract infections (LRTIs), elucidate the etiological spectrum of these infections, and explore the impact of mNGS on guiding antimicrobial therapy.

Methods

We retrospectively analyzed data from 128 patients admitted to the Respiratory Department of Anqing 116 Hospital between July 2022 and July 2023. All patients had undergone both mNGS and conventional microbiological techniques (CMT) for LRTI diagnosis. We assessed the diagnostic performance of these methods and examined the influence of mNGS on antimicrobial decision-making.

Results

Overall, mNGS demonstrated superior sensitivity (96.8%) a

SUBMITTER: Chen H 

PROVIDER: S-EPMC10983704 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature