Subsequent management and outcomes after first-line PARP inhibitors progression in ovarian cancer patients.

ABSTRACT:

Objectives

This retrospective study aims to evaluating the subsequent management and outcomes after first-line PARPi progression in Chinese ovarian cancer population.

Methods

Clinical and pathologic variables, treatment modalities, and outcomes were assessed. We investigated the subsequent management and outcomes after first-line PARPi progression. The objective response rate (ORR) and disease control rate (DCR) parameters were evaluated to determine the response to subsequent chemotherapy. For the survival analyses, progression-free survival 1 (PFS1), PFS2, overall survival (OS) and PFS2 - PFS1 were analysed.

Results

A total of 124 patients received PARPi maintenance treatment after first-line chemotherapy during the study period in our center. 44 of them (35.5%) exp

SUBMITTER: Yuan H 

PROVIDER: S-EPMC10983760 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature