Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma.

ABSTRACT:

Background

Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression.

Methods

NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as ≥ top and

SUBMITTER: Meagher M 

PROVIDER: S-EPMC10983807 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature