Dysregulated Ca²⁺ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogren's syndrome.

ABSTRACT: Saliva is essential for oral health. The molecular mechanisms leading to physiological fluid secretion are largely established, but factors that underlie secretory hypofunction, specifically related to the autoimmune disease Sjögren's syndrome (SS) are not fully understood. A major conundrum is the lack of association between the severity of inflammatory immune cell infiltration within the salivary glands and glandular hypofunction. In this study, we investigated in a mouse model system, mechanisms of glandular hypofunction caused by the activation of the stimulator of interferon genes (STING) pathway. Glandular hypofunction and SS-like disease were induced by treatment with 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid (DMXAA), a small molecule agonist of murine STING. Contrary to our expe

SUBMITTER: Huang KT 

PROVIDER: S-EPMC10983907 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature