Functional Redundancy in <i>Candida auris</i> Cell Surface Adhesins Crucial for Cell-Cell Interaction and Aggregation.

ABSTRACT: Candida auris is an emerging nosocomial fungal pathogen associated with life-threatening invasive disease due to its persistent colonization, high level of transmissibility and multi-drug resistance. Aggregative and non-aggregative growth phenotypes for C. auris strains with different biofilm forming abilities, drug susceptibilities and virulence characteristics have been described. Using comprehensive transcriptional analysis we identified key cell surface adhesins that were highly upregulated in the aggregative phenotype during in vitro and in vivo grown biofilms using a mouse model of catheter infection. Phenotypic and functional evaluations of generated null mutants demonstrated crucial roles for the adhesins Als5 and Scf1 in mediating cell-cell adherence, c

SUBMITTER: Wang TW 

PROVIDER: S-EPMC10983922 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature