Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism¹². For example, PDAC utilizes and is dependent on high levels of autophagy and other lysosomal processes^3-5. Although targeting these pathways has shown potential in preclinical studies, progress has been hampered by the challenge of identifying and characterizing favorable targets for drug development⁶. Here, we characterize PIKfyve, a lipid kinase integral to lysosomal functioning⁷, as a novel and targetable vulnerability in PDAC. In human patient and murine PDAC samples, we discovered that PIKFYVE is overexpressed in PDAC cells compared to adjacent normal cell

SUBMITTER: Cheng C 

PROVIDER: S-EPMC10983929 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature