Integrated analysis of gut metabolome, microbiome, and brain function reveal the role of gut-brain axis in longevity.

ABSTRACT: The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 participants, including 83 nonagenarians (NAs) and 81 non-nonagenarians (NNAs) matched with their spouses and offspring. We found that 438 metabolites were significantly different between the two groups; among them, neuroactive compounds and anti-inflammatory substances were enriched in NAs. In addition, increased levels of neuroactive metabolites in NAs were significantly associated with NA-enriched species that had three corresponding biosynthetic potentials: Enterocloster asparagiformis, Hungatella hathewayi and Oxalobacter formigenes<

SUBMITTER: Jiao B 

PROVIDER: S-EPMC10984123 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature