Oral pathobiont <i>Klebsiella</i> chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa.

ABSTRACT: The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut colonization by orally derived Klebsiella spp. has been linked to IBD in mice and humans. However, the mechanisms whereby oral pathobionts colonize extra-oral niches, such as the gut mucosa, remain largely unknown. Here, we performed a high-density transposon (Tn) screening to identify genes required for the adaptation of an oral Klebsiella strain to different mucosal sites - the oral and gut mucosae - at the steady state and during inflammation. We find that K. aerogenes, an oral pathobiont associated with both oral and gut inflammation in mice, harbors a newly identified g

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10984132 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature