Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress.

ABSTRACT:

Objective

The goal of this research was to evaluate the effect of DM type 2 (DM2) on SE severity, neurodegeneration, and brain oxidative stress (OS) secondary to seizures.

Methods

DM2 was induced in postnatal day (P) 3 male rat pups by injecting streptozocin (STZ) 100 mg/kg; control rats were injected with citrate buffer as vehicle. At P90, SE was induced by the lithium-pilocarpine administration and seizure latency, frequency, and severity were evaluated. Neurodegeneration was assessed 24 h after SE by Fluoro-Jade B (F-JB) staining, whereas OS was estimated by measuring lipid peroxidation and reactive oxygen species (ROS).

Results

DM2 rats showed an increase in latency to the first generalized seizure and SE onset, had a higher number and a longer duration of seizure

SUBMITTER: Ramos-Riera KP 

PROVIDER: S-EPMC10984310 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature