Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure.

ABSTRACT: Binge drinking during adolescence can have behavioral and neurobiological consequences. We have previously found that adolescent intermittent ethanol (AIE) exposure produces sex-specific social alterations indexed via decreases of social investigation and/or social preference in rats. The prelimbic cortex (PrL) regulates social interaction, and alterations within the PrL resulting from AIE may contribute to social alterations. The current study sought to determine whether AIE-induced PrL dysfunction underlies decreases in social interaction evident in adulthood. We first examined social interaction-induced neuronal activation of the PrL and several other regions of interest (ROIs) implicated in social interaction. Adolescent male and female cFos-LacZ rats were exposed to water (control) or

SUBMITTER: Towner TT 

PROVIDER: S-EPMC10984351 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature