Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.

ABSTRACT: Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.¹ show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.

SUBMITTER: Orme JJ 

PROVIDER: S-EPMC10984391 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature