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Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.

ABSTRACT: Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.¹ show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.

SUBMITTER: Orme JJ

PROVIDER: S-EPMC10984391 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.

Orme Jacob J JJ Mer Georges G Huang Haojie H

Molecular cell 20230301 5

Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.<sup>1</sup> show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy. ...[more]

PMID: 36868187

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