Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.

ABSTRACT:

Introduction

Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.

Method

We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).

Results

Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flort

SUBMITTER: Su Y 

PROVIDER: S-EPMC10984430 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature